A PMN-derived factor that enhances DNA-synthesis in PHA or antigen-stimulated lymphocytes.
Open Access
- 1 January 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 124 (1) , 94-99
- https://doi.org/10.4049/jimmunol.124.1.94
Abstract
The DNA synthesis potentiation of a mouse polymorphonuclear leukocyte (PMN) factor was studied by using phytohemagglutinin (PHA)-stimulated syngeneic thymocytes. The partially purified PMN factor was nonmitogenic and exhibited maximum potentiation of thymocytes when added within 3 hr of PHA stimulation. PHA-stimulated, but not nonstimulated thymocytes absorbed PMN potentiation factor. 125I-labeled factor binding to stimulated thymocytes was observed. Our results suggest that an acceptor site for PMN factor may be generated on the thymocyte surface only after PHA stimulation.This publication has 0 references indexed in Scilit: