N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations
- 1 July 2008
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 97 (7) , 2568-2580
- https://doi.org/10.1002/jps.21196
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugsClinical Pharmacology & Therapeutics, 2006
- EVALUATION OF MICRODOSING TO ASSESS PHARMACOKINETIC LINEARITY IN RATS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRYDrug Metabolism and Disposition, 2006
- Whatever happened to cassette-dosing pharmacokinetics?Drug Discovery Today, 2004
- Pharmaceutical profiling in drug discoveryDrug Discovery Today, 2003
- A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4Published by Elsevier ,2001
- Combining high-throughput pharmacokinetic screens at the hits-to-leads stage of drug discoveryDrug Discovery Today, 2000
- Direct Plasma Sample Injection in Multiple-Component LC−MS−MS Assays for High-Throughput Pharmacokinetic ScreeningAnalytical Chemistry, 1999
- Use of “N-in-one” Dosing to Create an in Vivo Pharmacokinetics Database for use in Developing Structure—Pharmacokinetic RelationshipsJournal of Pharmaceutical Sciences, 1999
- Managing the drug discovery/development interfaceDrug Discovery Today, 1997
- Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4Biochemistry, 1997