Effect of cancer and fasting on oxidation of labeled acetate, glucose and glycine to C14O2

Publisher Website
Google Scholar
Abstract
Acetate-2-C14, glucose-C146 and glycine-2-C14 metabolism was studied in rats as a function of fasting and tumor growth. So measured, acetate metabolism was not affected, glucose utilization was at first depressed and later showed a moderate increase. Glycine was conserved in the tumor-bearing rat during the period of weight gain, but oxidation to CO2 markedly increased during weight loss in both the fasted and tumorous animals. The glycine and glucose rate curves all showed a delay of the peak specific activity time with fasting, presumably a result of depressed intermediary metabolic rates.

This publication has 1 reference indexed in Scilit: