PROTECTIVE EFFECT OF STEROIDS AGAINST ACUTE EGG-WHITE TOXICITY IN ADRENALECTOMIZED RATS
- 1 July 1952
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 51 (1) , 21-25
- https://doi.org/10.1210/endo-51-1-21
Abstract
A method is descr. for screening the cortisone-like activity of compounds as measured by protection against the lethal effect of fresh egg-white in adrenalectomized rats. A comparison was made of the effectiveness of cortisone acetate, dehydrocorticosterone, 17-hydroxycorticosterone, and 6,7-dehydrocorticosterone in preventing egg-white-induced death. Cortisone acetate was 2.5 times more effective (within the range of one standard error) than dehydrocorticosterone and approx. 75 and 50% as effective as 17-hydroxycorticosterone and 6,7-dehydrocortisone, resp. A number of the steroids, antihistaminics, epinephrine, and rutin are ineffective in combating the lethality of egg-white by this test procedure.Keywords
This publication has 2 references indexed in Scilit:
- Effect of Epinephrine, Antihistaminics and Adrenergic Blockade on Egg White Edema in Adrenal Insufficient Rats.Experimental Biology and Medicine, 1949
- THE BIOASSAY OF ADRENAL CORTICAL STEROIDSAnnals of the New York Academy of Sciences, 1949