E2F1 and Telomerase: Alliance in the Dark Side

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Abstract
Cancer arises from a stepwise accumulation of genetic changes. Among these changes,deregulation of the Rb/E2F1 pathway and constitutively active telomerase are pivotalmilestones for the attainment of immortality and maintaining the neoplastic phenotype.We recently showed the Rb/E2F1 pathway to be a direct modulator of telomerase activityin normal and cancer cells, specifically in malignant gliomas. In addition, we reportedthat the correlation between the levels of expression of E2F1 and hTERT -the catalyticsubunit of telomerase- in a subset of patients with glioblastoma multiforme confersclinical relevance to the role of E2F1 in triggering or maintaining hTERT expression.Here we review the evidence supporting the mechanistic linkage between E2F1 andtelomerase activation. We also consider the clinical implications of this association interms of prognostic significance and opportunities for the development of new and morerational therapeutic strategies.

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