Prostaglandin E 1 Inhibits Platelet Aggregation by a Pathway Independent of Adenosine 3′,5′-Monophosphate
- 14 April 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4338) , 202-203
- https://doi.org/10.1126/science.204997
Abstract
Aggregation of human blood platelets induced by adenosine diphosphate or l -epinephrine was inhibited when the platelets were suspended in plasma which had been previously exposed to an insolubilized ω-aminohexylagarose derivative of prostaglandin E 1 . This decrease of platelet aggregation was not accompanied by a change in the concentration of adenosine 3′,5′-monophosphate (cyclic AMP) in platelets. The results demonstrate the existence of an alternative pathway independent of cyclic AMP for the inhibition of platelet aggregation by plasma.This publication has 19 references indexed in Scilit:
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