Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation

1 January 2007

journal article
Published by Taylor & Francis in Cancer Biology & Therapy

Vol. 6 (1) , 64-69
https://doi.org/10.4161/cbt.6.1.3549

Abstract

Our previous studies demonstrated that inhibition of histone deacetylases (HDACs) by trichostatin A reactivates estrogen receptor alpha (ER) gene expression in ER-negative breast cancer cells. Here...

Keywords

PROTEIN
GENE EXPRESSION
CHROMATIN
TREATMENT
HDAC INHIBITOR
REACTIVATED SILENCED
SILENCED ER

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