Myelodysplastic syndrome with eosinophilia in bone marrow
- 1 August 1993
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 84 (4) , 636-638
- https://doi.org/10.1111/j.1365-2141.1993.tb03139.x
Abstract
Summary. Clinical features were investigated in 114 patients with de novo myelodysplastic syndrome (MDS) diagnosed over the past 10 years, and eight cases (7%) were complicated with eosinophilia in the bone marrow. Two patients had refractory anaemia (RA), five had RA with excess of blasts (RAEB), and one had RAEB in transformation. Their bone marrow cells exhibited trilineage dysplasia and morphological abnormalities in eosinophils. Cytogenetics revealed major karyotype abnormalities (MAKA) in five patients. Survival durations were significantly shorter than those of other MDS patients. Our study suggests that marrow eosinophilia in MDS is strongly related to the coexistence of MAKA.Keywords
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