THE SENSITIVITY TO HYPERTENSIN, ADRENALIN AND RENIN OF UNANESTHETIZED NORMAL, ADRENALECTOMIZED, HYPOPHYSECTOMIZED AND NEPHRECTOMIZED DOGS

Publisher Website
Google Scholar
Abstract
The sensitivity of unanesthetized normal, adrenalectomized, and nephrectomized (uremic) dogs to 2 units of hypertensin, 10 7 of adrenalin, and 2 cc of a soln. of hog renin was detd. 48 hrs. after bilateral adrenalectomy, the sensitivity to hypertensin and adrenalin was usually normal unless terminal shock appeared. The sensitivity to renin was sometimes normal and sometimes reduced. The decrease in the sensitivity to renin at a time when the vessels were reacting normally to hypertensin was associated in 4 instances with a fall in the conc. of hypertensin precursor (hypertensinogen) in the plasma. Dogs hypophysectomized 1 mo. to 3 yrs. previously reacted normally to the inj. of hypertensin, adrenalin, and renin. Chloralosed dogs recently nephrectomized reacted normally to hypertensin and adrenalin and usually to renin. In 3 of 9 dogs the pressor effect of renin was greater and in 2 of 9 it lasted distinctly longer than in normal controls. Unanesthetized uremic dogs were frequently hypersensitive to hypertensin, adrenalin, and renin which was attributed to an increased reactivity of the vessels, an increase in the amt. of hypertensin precursor in uremic plasma, and the slow destruction of renin in uremic animals.

This publication has 13 references indexed in Scilit: