Sclérœdème de Buschke et dysglobulinémie monoclonale: à propos de 3 observations

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Abstract
A monoclonal gammopathy was observed in 3 adult patients with long-term and widespread scleredema (Buschke’s disease). There was no evidence of multiple myeloma in any patient. The monoclonal immunoglobulin was in every case of the IgG-ĸ type. Bence Jones proteinuria was noted in 1 case (ĸ). Deposition of monoclonal lgG-ĸ in the skin was not detected by immunofluorescence microscopy. These findings and previous reports of 5 cases suggest that diffuse scleredema may be frequently associated with paraproteinemia, but the role of monoclonal immunoglobulins in the pathogenesis of the disease remains to be clarified.

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