Inhibition of Adrenal Cortical Secretion by Amino-glutethimide in Dogs1

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Abstract
The acute effect of intravenous administration of amino-glutethimide (25, 50, 75 mg/kg of body wt) on adrenal venous plasma 17-hydroxycorticoid [17-OHCSj secretion has been studied in the dog. In spite of a continuous ACTH infusion, each injection of amino-glutethimide produced a prompt fall in the secretion of 17-OHCS. Control values were not regained 2 1/2 hr. following amino-glutethimide. Fractionation of the adrenal venous plasma samples for individual steroids after amino-glutethimide administration revealed a decrease in cortisol and corticosterone with no detectable pregnenolone, 17-hy-droxypregnenolone, progesterone, 17-hydroxyprogesterone, dehydro-epiandrosterone, deoxycorticosterone and substance S. These observations, along with previous findings of increased adrenal cholesterol and lipid content, are in keeping with the view that amino-glutethimide interferes with the conversion of cholesterol to pregnenolone in the dog.

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