MORPHOLOGY OF MENINGOPNEUMONITIS VIRUS EXPOSED TO PENICILLIN AS OBSERVED WITH THE ELECTRON MICROSCOPE

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Abstract
A sequential study was conducted of the morphological changes occurring in the developmental cycle of meningopneumonitis virus under the influence of penicillin as observed in thin sections with the electron microscope. When a mixture of the virus and penicillin was inoculated intra-allanto-ically into embryonated eggs, the matrix began to appear in the cytoplasm of entodermal cells of the allantois at the same time and with almost the same incidence as in controls. Under the influence of penicillin the normal process of segmentation of the matrix into masses the size of incomplete forms, and of incomplete and large forms into smaller viral particles was interfered with remarkably. Consequently, various aberrant forms were produced, while the development of intermediate forms and elementary bodies was disturbed. The abnormally developed viral forms underwent gradual disintegration. It has been inferred from these observations that the matrix formation and the multiplication by segmentation observed in the developmental cycle of meningopneumonitis virus involve two different processes.