Effect of d-Nicotine on the l-Nicotine-lnduced Increase in Gastric Acid Secretion in Rats
Open Access
- 1 January 1985
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 37 (2) , 215-217
- https://doi.org/10.1254/jjp.37.215
Abstract
D-Nicotine (1000 micrograms) applied into the cerebral ventricle of urethane anesthetized rats increased gastric acid secretion. When 50 micrograms of d-nicotine was concomitantly administered with 5 micrograms of 1-nicotine, the 1-nicotine-induced increases in gastric secretion was blocked. The appearance of convulsion induced by I-nicotine in mice was also inhibited by pretreatment with d-nicotine. These results suggest that d-nicotine has agonistic and antagonistic actions to I-nicotine in the central nervous system and that its agonistic potency varies with preparations.Keywords
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