Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets
- 15 October 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 263 (2) , 621-624
- https://doi.org/10.1042/bj2630621
Abstract
The [32P]PIP2/[32P]PA and the [32P]PIP/[32P]PA relationships were demonstrated to be remarkably similar after stimulation of [32P]P2-prelabelled platelets for 90 s with various combinations and concentrations of agonists and inhibitors. Thus the activity of the PI and PIP kinases with the corresponding phosphomonoesterases may be tightly controlled during receptor-mediated platelet stimulation involving phospholipase C activation.This publication has 22 references indexed in Scilit:
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