Cyclic AMP concentrations in plasma, cerebrospinal fluid and urine in patients with acute cerebral hemispheric infarction.

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Abstract
Plasmas, CSF and urine were sampled from 22 patients were cerebral hemispheric infarction and analyzed for cAMP. In mild cases with slight dysarthria and/or hemiparesis, but without disturbance of consciousness (group I), cAMP in peripheral venous plasma (PVP) remained over the normal lowest level more than 10 days after the onset. Patients with apparent neurological deficits could be divided into 2 groups. In 1 group cAMP in PVP decreased to a subnormal level within .apprx. 5 days after the onset of stroke (group II). In the other group (group III), no decrease was observed. Brain isotope scintigrams were negative in group I. The size of brain infarct as judged by isotope uptake was larger in group III than in group II, except for a few cases in which the lesion was restricted in the basal ganglionic region. No clinical significance was found in the time course of cAMP levels in internal jugular venous or femoral arterial plasma, in CSF or of the daily amount of cAMP excretion into urine. Cerebral arteriovenous difference of cAMP was negative in most cases.

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