Quinacrine (Atebrin): Mode of Action
- 5 May 1967
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3775) , 655-656
- https://doi.org/10.1126/science.156.3775.655
Abstract
Quinacrine at a concentration of 8 x 10-4 mole per liter is bactericidal for Escherichia coli, blocks DNA synthesis, and inhibits the syntheses of RNA and protein strongly. At a concentration of 2x 10-4 mole per liter, the drug is bacteriostatic, the syntheses of protein and DNA (but not that of RNA) are partially inhibited, and the bacteria grow into giant filaments. Impairment of DNA replication is proposed as the mode of action of quinacrine.Keywords
This publication has 7 references indexed in Scilit:
- The antimutagenic action of polyamines: suppression of the mutagenic action of an E. coli mutator gene and of 2-aminopurine.Proceedings of the National Academy of Sciences, 1966
- Chloroquine: Mode of ActionScience, 1966
- DEOXYRIBONUCLEIC ACID DEPENDENT RIBONUCLEIC ACID SYNTHESIS IN THE CROWN-GALL TUMOR-INDUCING ORGANISM AGROBACTERIUM TUMEFACIENSCanadian Journal of Biochemistry and Physiology, 1963
- Bacteriocidal action of mitomycin CBiochimica et Biophysica Acta, 1961
- The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium bergheiBiochemical Pharmacology, 1961
- The metabolism of Plasmodium berghei, the malaria parasite of rodents. 2. An effect of mepacrine on the metabolism of glucose by the parasite separated from its host cellBiochemical Journal, 1961
- In vitro Effects of Quinine, Atabrine and Substituted Acridine Compounds upon Gram Negative BacteriaExperimental Biology and Medicine, 1943