Carbenicillin Treatment of Pseudomonas Pulmonary Infection

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Abstract
Thirteen courses of carbenicillin were given to ten children with cystic fibrosis and pulmonary infections due to Pseudomonas aeruginosa. There was clinical improvement following antimicrobial therapy in seven children; however, four children ultimately died. Carbenicillin alone or in combination with polymyxin B sulfate or gentamicin sulfate did not eradicate P aeruginosa from the sputum. There was poor correlation of the clinical result of therapy with the susceptibility of the infecting organism. The only adverse result of carbenicillin administration was a reversible rise in serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase noted during therapy.