Acute effect of glycerol on net cerebrospinal fluid production in dogs
- 1 November 1985
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 63 (5) , 759-762
- https://doi.org/10.3171/jns.1985.63.5.0759
Abstract
✓ The effect of glycerol administration on cerebrospinal fluid (CSF) formation in dogs was studied by means of a ventriculocisternal perfusion technique. Net CSF production rate decreased after oral administration of glycerol (3 gm/kg) from a baseline level of 42.33 ± 6.68 µl/min (mean ± standard error) to a trough of 10.33 ± 4.88 µl/min at 90 minutes after administration (p < 0.025). Serum osmolality concomitantly increased from a baseline value of 296 ± 2.83 to 309 ± 4.7 mOsm/kg H2O at 90 minutes. The mean percentage change in CSF production inversely correlated to the mean percentage change in serum osmolality, r = −0.85. Thus, glycerol administration decreases net CSF formation, and this effect may be related in part to the rise in serum osmolality.Keywords
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