Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation.
- 1 May 1991
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (9) , 3792-3796
- https://doi.org/10.1073/pnas.88.9.3792
Abstract
Magainins are an ionophoric class of vertebrate peptides with antibiotic activity against various microorganisms. Here we show that magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor target cells with a relative cytotoxic potency that parallels their antibacterial efficacy and at concentrations that are relatively nontoxic to well-differentiated cells. The cytotoxicity is prevented by cell depolarization. Magainins represent a natural cytolytic agent in vertebrates and may provide another therapeutic strategy for certain tumors.Keywords
This publication has 12 references indexed in Scilit:
- Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayersBiophysical Journal, 1989
- Magainins and the disruption of membrane-linked free-energy transduction.Proceedings of the National Academy of Sciences, 1989
- Magainin 2 amide and analogues Antimicrobial activity, membrane depolarization and susceptibility to proteolysisFEBS Letters, 1989
- Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesiclesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- In vitro cytocidal effect of lytic peptides on several transformed mammalian cell lines.1989
- Synthetic magainin analogues with improved antimicrobial activityFEBS Letters, 1988
- Activation of Ca2+-dependent K+ channels in human B lymphocytes by anti-immunoglobulin.Journal of Clinical Investigation, 1988
- A two‐dimensional NMR study of the antimicrobial peptide magainin 2FEBS Letters, 1988
- Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.Proceedings of the National Academy of Sciences, 1987
- Lymphocyte membrane potential and Ca2+‐sensitive potassium channels described by oxonol dye fluorescence measurementsJournal of Cellular Physiology, 1985