Effect of Intrinsic Factor Concentrates on Vitamin B12 Receptor Protein of Tissues.

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Abstract
Data are presented which show that intrinsic factor containing materials will stimulate receptor proteins to combine vitamin B12 of tissues as well as serum. Further, the receptor proteins of tissues are located intracellularly in the microsome and soluble protein fraction of liver homogenates. The evidence suggests that intrinsic factor aids in absorption of vitamin B12 by stimulating the intracellular receptor proteins to combine with vitamin B12.