Massive Hematuria and Perforation in a Case of Amyloidosis of the Bladder: Case Report and Review of the Literature

Abstract
Perforation of the bladder is reported for the 1st time in a case of amyloidosis. The perforation was caused by massive hematuria. Based on repeated cystoscopic observations, this alteration of the bladder wall is progressive and caused by the damaging effect of a continuing growing clot on poorly vascularized tissues. A review of 5 other cases of secondary amyloidosis complicated by massive hematuria indicates that hemorrhage occurs in advanced stages of the disease, has a gloomy prognosis and may precipitate the final outcome.