Changes in Hypertensinase and Hypertensinogen Following Nephrectomy

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Abstract
The hypertensinase content of dog's plasma is decreased 48 hours after nephrectomy. This decrease may contribute to the increased blood pressure response to renin shown by nephrectomized animals. When plasma is incubated with a relatively small concentration of renin, the yield of hypertensin increases after nephrectomy. This finding correlates with decreased hypertensinase and the increased pressor response to renin characteristic of the postnephrectomy state. Mean plasma hypertensinogen shows about a threefold increase, and its significance is discussed.

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