An Improved Synthesis of 3-Methyl-5-hydroxy Protected Indoles
- 1 March 1994
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 24 (6) , 839-848
- https://doi.org/10.1080/00397919408011306
Abstract
The synthesis of 3-methyl-5-alkoxy indoles 14 and 15 was accomplished through the use of DIBALH to effect the reductive-cyclization of an amino-nitrile intermediate. The mild conditions used to induce cyclization allowed for the use of a benzyl protecting groups which is normally sensitive to palladium catalyzed reducing conditions.Keywords
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