A population-based family study (II): Segregation analysis
- 1 January 1997
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 14 (6) , 945-949
- https://doi.org/10.1002/(sici)1098-2272(1997)14:6<945::aid-gepi64>3.0.co;2-l
Abstract
We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.Keywords
This publication has 2 references indexed in Scilit:
- The Eiston-Stewart Algorithm for Continuous Genotypes and Environmental FactorsHuman Heredity, 1992
- Compound Regressive Models for Family DataHuman Heredity, 1992