THE ROLE OF UROCANIC ACID IN UV‐INDUCED IMMUNOSUPPRESSION: RECENT ADVANCES (1992–1994)
- 1 August 1995
- journal article
- review article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 62 (2) , 209-217
- https://doi.org/10.1111/j.1751-1097.1995.tb05261.x
Abstract
— Cis ‐ urocanic acid (UCA), formed in the epidermis by UV irradiation of trans‐UCA, has been implicated as a mediator of the immunosuppression induced by UV exposure of the skin. This review covers recent work in which the wavelength dependence of cis‐UCA formation, the interaction of UCA isomers with DNA, the effects of UCA isomers on the immune system and their interaction with histamine are examined. Results are frequently conflicting, particularly when considering the possible mode of action of cis‐UCA but, overall, a multifaceted role for UCA in immunomodulation by UV radiation is substantiated.Keywords
This publication has 42 references indexed in Scilit:
- Fluorescent light activates the immunomodulator cis-urocanic acid in vitro: implications for patients with systemic lupus erythematosus.Annals of the Rheumatic Diseases, 1994
- Trans-urocanic acid, a natural epidermal constituent, inhibits human natural killer cell activity in vitroExperimental Dermatology, 1994
- ADVENTITIOUS INTERCONVERSION OF cis- AND trans-UROCANIC ACID BY LABORATORY LIGHTPhotochemistry and Photobiology, 1994
- PHOTOSENSITIZED INACTTVATION OF INFECTIOUS DNA BY UROCANIC ACID, INDOLEACRYLIC ACID AND RHODIUM COMPLEXESPhotochemistry and Photobiology, 1994
- A GARLIC EXTRACT PROTECTS FROM ULTRAVIOLET B (280–320 nm) RADIATION‐INDUCED SUPPRESSION OF CONTACT HYPERSENSITIVITYPhotochemistry and Photobiology, 1993
- IL-12: Initiation Cytokine for Cell-Mediated ImmunityScience, 1993
- ACTION SPECTRA FOR THE trans TO cis PHOTOISOMERISATION OF UROCANIC ACID in vitro and IN MOUSE SKINPhotochemistry and Photobiology, 1993
- Cis‐UROCANIC ACID DOWN‐REGULATES THE INDUCTION OF ADENOSINE 3', 5'‐CYCLIC MONOPHOSPHATE BY EITHER trans‐UROCANIC ACID OR HISTAMINE IN HUMAN DERMAL FIBROBLASTS in vitroPhotochemistry and Photobiology, 1992
- Immunosuppression by ultraviolet B radiation: initiation by urocanic acidImmunology Today, 1992
- Cis-Urocanic Acid, a Product formed by Ultraviolet B Irradiation of the Skin, Initiates and Antigen Presentation Defect in Splenic Dendritic Cells In VivoJournal of Investigative Dermatology, 1988