Further Study into Obstructive Jaundice and Ischaemic Renal Damage
- 26 April 1969
- Vol. 2 (5651) , 229-231
- https://doi.org/10.1136/bmj.2.5651.229
Abstract
Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.Keywords
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