Activation of the PKC‐isotypes α, β1, γ, δ, and ε by phorbol esters of different biological activities
Open Access
- 19 August 1991
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 288 (1-2) , 5-9
- https://doi.org/10.1016/0014-5793(91)80989-g
Abstract
Phorbol esters, tetradecanoylphorbolacetate, sapintoxin-A, 12-deoxyphorbol-phenylacetate, 12-deoxyphorbol-phenylacetate-20-acetate, thymeleatoxin and resiniferatoxin were investigated for their abilities to activate the PKC-isotypes α, β1, γ, δ and ε. PKC-isotypes were grouped into two classes on the basis of Ca2+ requirements for activation by phorbol esters; α, β1, and γ being Ca2+-dependent forms and δ and ε being Ca2+-independent. PKC-isotype selective activation by phorbol esters was observed in that SAPA failed to activate PKC-δ up to a concentration of 1000 ng ml−1 and DOPPA only activated PKC-β1, over the same range of concentrations.Keywords
This publication has 27 references indexed in Scilit:
- TPA and resiniferatoxin-mediated activation of NADPH-oxidaseFEBS Letters, 1990
- A phorbol ester and a daphnane ester stimulate a calcium‐independent kinase activity from human mononuclear cellsFEBS Letters, 1989
- Tumour-promoting and hyperplastic effects of phorbol and daphnane esters in CD-1 mouse skin and a synergistic effect of calcium ionophore with the non-promoting activator of protein kinase C, sapintoxin ACarcinogenesis: Integrative Cancer Research, 1989
- Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversityFEBS Letters, 1989
- The effects of phorbol esters with different biological activities on protein kinase CPhytotherapy Research, 1987
- Irritant resiniferonol derivatives from EgyptianThymelaea hirsuta L.Cellular and Molecular Life Sciences, 1984
- Sapintoxin A, a new biologically active nitrogen containing phorbol esterCellular and Molecular Life Sciences, 1981
- Some Naturrally Occurring Skin IrritantsActa Pharmacologica et Toxicologica, 1975
- Synergistic action of phorbol esters in mitogen-activated bovine lymphocytesExperimental Cell Research, 1974
- THE TUMOR-PROMOTER PHORBOL ESTER (12-0-TETRADECANOYL-PHORBOL-13-ACETATE), A POTENT AGGREGATING AGENT FOR BLOOD PLATELETSThe Journal of cell biology, 1974