EFFECTS OF BRADYKININ MEDIATED BY AUTONOMIC EFFERENT NERVES

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Abstract
Intra-arterial injections of bradykinin to cats causes increases in blood pressure and increased impulse rates in single sympathetic efferent fibers. The peptide also causes 1 or more large bladder contractions, which are associated with increased impulse rates in pelvic nerve efferent fibers whose spontaneous discharges are temporally associated with increases in intravesical pressure. These induced increases in pelvic nerve discharge and intravesical pressure could be abolished or greatly reduced by interference with conduction in pathways which mediate reflex bladder contractions. Bradykinin has little direct action on the bladder; the large contractions which result from its administration are mediated by the CNS.