Signal search analysis: a new method to localize and characterize functionally important DNA sequences
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (1Part1) , 287-305
- https://doi.org/10.1093/nar/12.1part1.287
Abstract
The generation of "signal search data" represents a general method of describing the common properties of a set of DNA sequences presumed to be functionally analogous. Besides the detailed description of this method we present two computer programs which use signal search data as input data: One that processes them to a "constraint profile" and another one which lists over-represented "signals" of potential functional relevance. To illustrate the possibilities of our method we have analysed a set of transcription initiation sites of sea urchin histone genes.Keywords
This publication has 9 references indexed in Scilit:
- Use of the ‘Perceptron’ algorithm to distinguish translational initiation sites inE. coliNucleic Acids Research, 1982
- Characterization of translational initiation sites inE. coliNucleic Acids Research, 1982
- Comparative analysis of nucleic acid sequences by their general constraintsNucleic Acids Research, 1982
- Ubiquitous and gene-specific regulatory 5′ sequences in a sea urchin histone DNA clone coding for histone protein variantsNucleic Acids Research, 1980
- Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.Proceedings of the National Academy of Sciences, 1980
- Leader sequences of Strongylocentrotus purpuratus histone mRNAs start at a unique heptanucleotide common to all five histone genes.Proceedings of the National Academy of Sciences, 1980
- Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptorNucleic Acids Research, 1976
- Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coliNature, 1975