The Use of Computer Programs for Tissue Typing and Immunogenetic Research

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Abstract
Experience in the use of electronic data processing for tissue typing and immunogenetic research is presented and some of the important features of typing programs are discussed. The cell typing program is set up for the use of updated serum information. It forms the basis for a summary analysis of the 2 × 2 tables which includes correlation coefficients, phenotype frequencies, gene frequencies, haplotype frequencies, and the linkage disequilibrium parameter (delta). A minimumX2program is described for the test of the Hardy‐Weinberg equilibrium and for the estimate of gene frequencies. The family analysis lists the sera according to the different backcrosses and according to the specificities, and assigns the paternal chromosomes to the offspring.The sera typing program gives criteria for sera selection: strength of reaction, frequency and false positive and negative reactions in relation to the typed specificity. The detection of new antigens is described in a few theoretical examples.

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