Absorption, distribution and excretion of SCE-963, a new broad-spectrum cephalosporin, in mice, rats, rabbits and dogs.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (12) , 1272-1282
- https://doi.org/10.7164/antibiotics.31.1272
Abstract
A single dose of 20 mg/kg of SCE-963 [7.beta.-[2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acid] was administered s.c. to mice and i.m. to rats, rabbits and dogs. Plasma and tissue levels of SCE-963 reached a peak in 15-30 min after administration. In mice, rats and dogs, SCE-963 was distributed at high concentration in descending order in the kidney, liver, plasma, lung and spleen, and in rabbits, in the kidney, plasma, lung, liver and spleen. The SCE-963 levels in the liver of mice, rats and dogs were higher than those of cefazolin, cephaloridine and cephalothin. The plasma and tissue levels of SCE-963 in mice and rats diminished rapidly, but those in rabbits and dogs declined gradually. SCE-963 was mainly excreted in the urine. The rate of excretion of SCE-963 in the bile was 2-3 times higher than that of cefazolin.This publication has 1 reference indexed in Scilit:
- Penetration of antimicrobial agents into bronchial secretionsThe American Journal of Medicine, 1975