GLOMERULAR LESIONS IN EXPERIMENTAL RENAL PAPILLARY NECROSIS .1. ULTRASTRUCTURAL ASPECTS AND SOME PATHOGENIC CONSIDERATIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (1) , 23-29
Abstract
Papillary necrosis was induced in rats by a single i.v. injection of bromoethylamine hydrobromide. From 7 days on, glomerular lesions were recognized. They consisted of electron dense deposits, mainly subepithelial in location, mild mesangial hypercellularity and matrix increase. Immunofluorescence with anti-rat .gamma.globulin was positive, showing granular fluorescence in relation to the basement membrane and mesangium. These lesions may be due to the pathogenic action of immune complexes, the antigen being one arising during the necrosis of the renal papilla. This mechanism can be operative in the human being in cases of papillary necrosis of the kidney.