Mechanism of Genitourinary Symptoms in Herpes Simplex Virus Infection

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To the Editor: The report on herpes simplex virus (HSV) proctitis by Goodell et al. (April 14 issue)1 is another important contribution by a group of investigators who have done much to clarify the epidemiology, clinical findings, and microbiology of sexually transmitted infections, especially in homosexual persons. I do think, however, that there is now enough accumulated evidence about HSV infection that the mechanism of the sacral neurologic dysfunction should no longer be considered obscure, as their paper suggests. After local inoculation, the herpes simplex viruses have an affinity for sensory-root ganglia presumably traveling along neural pathways.2 They then cause . . .