Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity
- 1 August 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 12 (suppl D) , 117-120
- https://doi.org/10.1093/eurheartj/12.suppl_d.117
Abstract
Immunization with purified cardiac myosin induces autoimmune myocarditis in A strain mice. Because this disease parallels Coxsackievirus B3 (CB3)-induced myocarditis in many respects, we are now using the immunization model as a virus-free system to study certain forms of immunologically-mediated heart disease. In the present article we will describe several characteristics of the humoral and cellular autoimmune response acting in myosin-induced myocarditis. Furthermore, we discuss hypotheses which might explain how myosin-reactive T cells recognize and attack the heart tissue.Keywords
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