Pathogen-host jujitsu: phagocyte impotence caused by internalized bacterial adenylate cyclase.

  • 1 January 1982
    • journal article
    • Vol. 95, 1-7
Abstract
Humans and animals infected with Bordetella species show evidence of impaired host defenses. These pathogenic bacteria produce a unique adenylate cyclase which enters human phagocytes and catalyzes the unregulated formation of cAMP, a known cellular inhibitor. This unique pathogen-host interaction may explain the unusual features of human B. pertussis infection and represents a powerful new probe for the investigation of cAMP-governed processes.

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