VOLUMETRIC AND MICROSCOPIC PATTERN OF BONE MARROW IN NORMAL INFANTS AND CHILDREN

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Abstract
The volumetric technic described is technically practical for the study of bone marrow in infants and children. Tibial aspirations show in general a progressive increase in fat and decrease in myeloid-erythroid layer with advancing age; after approximately 2½ years of age, many of the specimens reflect a relatively fatty and hypoplastic marrow. Iliac aspirations from individuals 18 months through 11 years of age yield volumetric values comparable to the values obtained from sternal aspirations. Sternal aspirations from 5 years through 11 years yield values similar to those reported in the older age ranges. With use of the technics described, the iliac site is technically superior to the sternum for the study of bone marrow of children from 18 months through 11 years; for those individuals less than 18 months of age, the tibia offers a practical site.

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