Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates.

This publication has 28 references indexed in Scilit:

• The complete amino acid sequence of hirudin, a thrombin specific inhibitor
  Published by Wiley ,2001
• Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex
  Biochemistry, 1989
• Thrombin Interactions with Hirudin
  Seminars in Thrombosis and Hemostasis, 1989
• The hirudin-binding site of human α-thrombin
  Journal of Biological Chemistry, 1989
• Design, synthesis and antithrombin activity for conformationally restricted analogs of peptide anticoagulants based on the C-terminal region of the leech peptide, hirudin
  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1988
• Interaction of hirudin with thrombin: identification of a minimal binding domain of hirudin that inhibits clotting activity
  Biochemistry, 1988
• Comparison of hirudin and hirudin PA C-terminal fragments and related analogs as antithrombin agents
  Thrombosis Research, 1988
• Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin
  Biochemistry, 1988
• N-Terminal requirements of small peptide anticoagulants based on hirudin 54-65
  Journal of Medicinal Chemistry, 1988
• Identification of regions of .alpha.-thrombin involved in its interaction with hirudin
  Biochemistry, 1987