Chronic administration of MK-801 and the NMDA receptor: Further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation
- 1 May 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 42 (5) , 354-355
- https://doi.org/10.1111/j.2042-7158.1990.tb05426.x
Abstract
Cortical slices removed from rats pre-treated with MK-901 0.5 mg kg−1 twice a day for 7 days had reduced responses to N-methyl-D-aspartate (NMDA) relative to quisqualate and glutamate compared with control animals. Potencies of competitive (CPMP) and non-competitive (ketamine) NMDA antagonists appeared unchanged. These changes are consistent with a reduced density of NMDA receptors.This publication has 3 references indexed in Scilit:
- Subchronic administration of MK-801 in the rat decreases cortical binding of [3H]d-AP5, suggesting down-regulation of the corticalN-methyl-d-aspartate receptorsNeuroscience, 1989
- A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonistsBritish Journal of Pharmacology, 1988
- Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligandsEuropean Journal of Pharmacology, 1988