Some Effects of Desoxycorticosterone Acetate on Mice Irradiated with X-rays.

Publisher Website
Google Scholar
Abstract
A reduction in mortality rate of mice irradiated with 500r/air (HVL. = 0.75 mmCu) in one exposure by the use of desoxycorticosterone acetate (DCA) has been demonstrated. Reduction in mortality rate has been correlated with the protective action of DCA against radiation induced liver changes. It has been shown that reduction in mortality rate and protection against radiation-induced liver changes are dependent, within limits, on the size of the daily dose of the hormone (0.25, 0.5 and 1.0 mg. daily). It has been suggested that the graded effect of DCA is possibly due to an antagonism to the indirect action of the X-rays which consists in the release of histamine-like substances from the irradiated tissues. The data presented are proposed as a pharmacologic basis which justifies the clinical use of DCA in the treatment of radiation sickness.

This publication has 1 reference indexed in Scilit: