Anopheles gambiae heat shock protein cognate 70B impedes o'nyong-nyong virus replication
Open Access
- 11 July 2007
- journal article
- Published by Springer Nature in BMC Genomics
- Vol. 8 (1) , 231
- https://doi.org/10.1186/1471-2164-8-231
Abstract
Phylogenetic and functional analysis was conducted on an Anopheles gambiae gene, ENSANGG00000017398. Based on phylogenetic analysis, this gene belongs to the same lineage as Heat shock protein cognate 70-4 (Hsc70-4) in Drosophila. Accordingly, we propose to name this gene Heat shock protein cognate 70B (HSC70B). We previously reported that expression of HSC70B and other genes including elongation factor-1α (EF-1α) and the agglutinin attachment subunit (agglutinin) were up-regulated in o'nyong-nyong virus (ONNV)-infected female An. gambiae. Double-stranded RNA interferences have been applied to further investigate HSC70B, EF-1α and the agglutinin functions in ONNV replication in An. gambiae.Keywords
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