Depression of the Platelet Count after Inoculation of Mice with L1210 or L5178Y Cells
- 1 March 1977
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 35 (3) , 465-471
- https://doi.org/10.1111/j.1365-2141.1977.tb00608.x
Abstract
The inoculation of L1210 or L5178Y leukemia cells decreased the platelet count of the recipient mouse before extensive infiltration of marrow was expected by either tumor line. The decrease was more pronounced after i.v. inoculation of L1210 leukemia than after i.p. inoculation. Inoculation of L5178Y cells by both routes caused an initial decrease but the count recovered to 80% of normal before becoming markedly depressed prior to death of the host. Implantation of diffusion chambers containing L1210 cells also decreased the platelet count, which later returned to normal.This publication has 4 references indexed in Scilit:
- Platelet—tumor‐cell interactions in mice. The role of platelets in the spread of malignant diseaseInternational Journal of Cancer, 1973
- Morphology and Enumeration of Human Blood PlateletsJournal of Applied Physiology, 1950
- Observations on the Effect of a Folic-Acid Antagonist on Transplantable Lymphoid Leukemias in Mice2JNCI Journal of the National Cancer Institute, 1949