Micellar electrokinetic capillary chromatography analysis of water‐soluble vitamins and multi‐vitamin integrators

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Abstract
Micellar electrokinetic capillary chromatography (MECC) was applied to the determination of water‐soluble vitamins (WSV) in pharmaceutical preparations. The analytical procedure employed in the WSV separation by MECC showed a satisfactory average column efficiency (195000 N) and resolution (more than 100 theoretical peaks separable). The mean reproducibility in the retention time of consecutive and day‐to‐day runs was 1.1% and 5.1%, respectively. Analyses were performed after extraction of active ingredients by solid phase extraction. Recoveries (92–103%) and relative variation coefficients (less than 5%) confirmed the potential of MECC in the field of pharmaceutical analysis.

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