H. The Kinetics of Enzyme Cascade Systems General kinetics of enzyme cascades

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Abstract
The theory of the kinetics of enzyme cascades is developed. Two types of cascades are recognized, one in which the products are stable (open cascades) and another in which the products are broken down (damped cascades). It is shown that it is a characteristic of a cascade that the final product appears after a certain lag phase. After this lag phase, the velocity of product formation can be very rapid. It is shown that whereas open cascades will always show a complicated time-product relation, damped cascades can under certain circumstances resemble a simple enzymic reaction. Because the relation between the over-all reaction velocity in the extrinsic coagulation cascade and the concentration of any of the proenzymes in this cascade is a hyperbolic one, it is concluded that this cascade is of the damped type rather than the open type.

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