Quantitative Aspects of the Enhancing Action of Eperythrozoa on the Pathogenicity of Mouse Hepatitis Virus

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Abstract
Mouse hepatitis virus (MHV 1) produces a mild, rarely fatal, hepatitis in weanling mice; when mice are infected simultaneously with Eperythrozoon coccoides fatal hepatitis is produced. This enhanced pathogenicity of MHV 1 virus is shown to result from the increased probability of virus particles actively infecting cells in the presence of the blood parasite. The enhancing effect of E. coccoides on the pathogenicity of MHV 1 is attributed to the parasite increasing the ratio of active to latent infections of cells by the virus.

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