Treatment of migraine has posed a problem for many years. Its severity and the tenacity of the symptoms have caused much concern to doctor and patient alike. The number and multiplicity of therapeutic agents and the uniformly good results reported with these medicaments indicate the unsatisfactory state of knowledge concerning treatment. The underlying causes of migraine are at present unknown. In fact, it is doubtful whether any single process or mechanism is responsible. Among the many theories that have been advanced, the vasomotor has long been popular. More than 70 years ago Dubois-Reymond1 ascribed the symptoms of migraine to tonic spasm of the muscular coats of the vessels. In recent years Wolff2 and his co-workers have objectively demonstrated a vasomotor imbalance involving spasm and dilatation. At present, most investigators explain the prodromes, course, symptoms, signs and sequelae of the disorder on the basis of changes in the cerebral