The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites
- 4 March 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4844) , 1150-1153
- https://doi.org/10.1126/science.2964084
Abstract
The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4+ human lymphoblast cell line, H9. These data suggest that several proteins may associate with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.Keywords
This publication has 31 references indexed in Scilit:
- The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologousCell, 1987
- Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fosCell, 1987
- Purified transcription factor AP-1 interacts with TPA-inducible enhancer elementsCell, 1987
- Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factorCell, 1987
- Kinetics of cellular oncogene expression in mouse lymphocytes II. Regulation of c‐fos and c‐myc gene expressionEuropean Journal of Immunology, 1987
- Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDSScience, 1986
- The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cellsGene, 1986
- Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active BenzodiazepinesScience, 1985
- The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeatCell, 1985
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970