Reduced-size liver transplantation (RLT)* was developed in the experimental laboratory in order to overcome the problem of space in auxiliary liver transplantation since the graft had to be made smaller to fit in the abdominal cavity of the recipient. Subsequently, RLT was used to transplant children with livers from older donors to overcome the shortage of pediatric organs for liver transplantation. This technique has been widely adopted in recent years, and has brought about improved results in the management of children with end-stage liver diseases (1–4). Clinical observations of children receiving OLT suggested that the grafts did not regenerate to their original size, but rather adapted to the needs of the host environment (1).