OBSERVATIONS ON THE SUBSTRATE SPECIFICITY OF AMINE OXIDASES

Open Access
Publisher Website
Google Scholar
Abstract
A number of compounds have been tested as substrates of, first, the amine oxidases of rabbit and guinea‐pig liver and of goat, pig, horse, and dog plasma and, second, the “diamine oxidase” of pig kidney. Of the three xylylenediamines [di(aminomethyl)benzenes] tested, m‐xylylenediamine was found to be a substrate of the liver oxidase. All the plasma oxidases tested acted on both m‐ and o‐xylylenediamine. Both 3‐ and 4‐picolylamine (3‐ and 4‐aminomethylpyridine) were readily oxidized by the liver enzymes; all the plasma oxidases tested oxidized 2‐, 3‐, and 4‐picolylamine. 4‐Picolylamine was more rapidly oxidized by horse and dog plasma than any other substrate hitherto examined.

This publication has 9 references indexed in Scilit: