TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter

Open Access

1 January 2004

journal article
research article
Published by Oxford University Press (OUP) in Bioinformatics

Vol. 20 (1) , 136-137
https://doi.org/10.1093/bioinformatics/btg394

Abstract

Summary: Web-based servers implementing the DAS-TMfilter algorithm have been launched at three mirror sites and their usage is described. The underlying computer program is an upgraded and modified version of the DAS-prediction method. The new server is designed to make distinction between protein sequences with and without transmembrane (TM) helices at a reasonably low rate of false positive prediction (∼1 among 100 unrelated queries) while the high efficiency of the original algorithm locating TM segments in queries is preserved (sensitivity of ∼95% among documented proteins with helical TM regions). Availability: The server operates at three mirror sites: http://mendel.imp.univie.ac.at/sat/DAS/DAS.html, http://wooster.bip.bham.ac.uk/DAS.html and http://www.enzim.hu/DAS/DAS.html. The program is available on request.

Keywords

This publication has 0 references indexed in Scilit: