The Binding of Cadmium Ions to the Smooth Muscle of Guinea-Pig Taenia Coli

Publisher Website
Google Scholar
Abstract
Tenia coli was used to study the property of binding of Cd2+. The Scatchard plots of Cd uptake showed that 2 qualitative Cd2+ binding sites (high and low affinity binding sites) existed in tenia coli. Decrease in Ca2+ concentration in the medium increased the Cd binding. The Scatchard analysis of Cd2+ binding in tenia coli at 4.degree. C indicated a single class of binding sites (only high affinity binding sites). The greater number of high affinity Cd2+ binding sites in tenia coli may have been related to the binding to cell membrane. It was postulated that some low affinity binding sites in tenia coli may have reflected intracellular accumulation, indicating action on the contractile system.